Overdosage has been reported with timolol maleate tablets. It is biotransformed in the liver. You can usually carry on taking the drops, unless the effects are serious.
Gently squeeze the contents of the vial directly onto your eyeball, picture 1. Therefore, do not open the single-use container until just before you are ready to use it. This helps to stop Timolol getting into the rest of the body.
Due to its negative effect on conduction time, beta-blockers should only be given with caution to patients with first degree heart block. The preparation is applied with care in senile patients and in children. Epidemiological studies have not revealed malformative effects but show a risk for intra uterine growth retardation when beta-blockers are administered by the oral route.
The therapy duration depends on the disease course and is determined by the physician. If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
A detailed paediatric history and examination to determine the presence of systemic abnormalities should precede the use of Timolol. The signs of overdosage include slow heart rate, drop of blood pressure, breathing difficulties, and heart attack.
A ratio of 2 is usually considered the criterion for a positive Ames test.
Remove contact lenses before using the eye drops and wait at least 15 minutes before reinserting. Anaphylactic reactions While taking beta-blockers, patients with history of atopy or a history of severe anaphylactic reaction to a variety of allergens may be more reactive to repeated challenge with such allergens and unresponsive to the usual dose of adrenaline used to treat anaphylactic reactions.
Your doctor will assess the correct dosage for you if you are transferring from another medicine. This medicine can cause temporary blurring of the vision. In newborns, infants and younger children Timolol should be used with extreme caution.
Low blood glucose levels Difficulty sleeping insomniadepression, nightmares, memory loss Signs and symptoms of eye irritation e. What Timolol is and what is it used for 2. If you experience a rare these may affect between 1 in 1, and 1 in 10, patients but serious allergic reaction difficulty breathing, closing of the throat, swelling of the lips, tongue, or face or hives to timolol, stop using the medication and contact your doctor immediately.
Similar differences were not observed in rats administered oral doses equivalent to approximately 14, times the maximum recommended human ophthalmic dose.
Try not to blink or rub your eye. Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including those medicines obtained without a prescription.
An in vitro hemodialysis study, using 14C timolol added to human plasma or whole blood, showed that timolol was readily dialyzed from these fluids; however, a study of patients with renal failure showed that timolol did not dialyze readily.
Tilt your head backwards and using your fingers pull your eye lids far apart. You should check with your doctor or pharmacist if you are not sure. If you miss a dose, skip the missed dose and go back to your regular dosage schedule.
Pregnancy and breast-feeding Do not use Timolol if you are pregnant unless your doctor considers it necessary. Keep using your medicine until your doctor tells you to stop. Pharmacokinetics Being applied locally timolol maleate penetrates the cornea.
The use of two topical beta-adrenergic blocking agents is not recommended see section 4. When using nasolacrimal occlusion or closing the eyelids for 2 minutes, the systemic absorption is reduced.The usual starting dose is one drop of % TIMOPTIC in the affected eye(s) twice a day.
If the clinical response is not adequate, the dosage may be changed to one drop of % solution in the affected eye(s) twice a day. Glaucol eye-drops contain the active ingredient Timolol Maleate BP along with the inactive ingredients sodium chloride, sodium hydroxide and water.
Glaucol eye-drops come in two strengths: % w/v & The preparation is used in the form of instillations into the lower conjunctival sac of the eye damaged.
The therapy is begun with % solution (1 drop 1 – 2 times/24 hours), in case the effect is not sufficient % solution is used (1 drop 1 – 2 times/24 hours). Sandoz has dorzolamide 2% and timolol % ophthalmic solution in 10 mL bottles on back order and the company estimates a release date of mid- to late-November Implications for Patient Care Each product contains dorzolamide hydrochloride mg/mL (equivalent to dorzolamide 2%) and timolol maleate mg/mL (equivalent to timolol %).
Topical application of timolol eye drop has been mentioned in few studies, most of which reported that the solution cannot stay on the site of application due to its fluidity. Adding hydroxyethyl cellulose into a timolol solution increased its viscosity by forming a hydrogel and thus changed the rheology property.
The usual starting dose is one drop of % eye drops into each affected eye(s) twice daily, approximately 12 hours apart. Your doctor will change your treatment as necessary. If you are using in combination with another eye drop medicine, wait minutes before applying the second eye drop.Download